No Extra Blood Clot Risk After Second Dose Of AstraZeneca Covid Vaccine: Study



No Extra Blood Clot Risk After Second Dose Of AstraZeneca Covid Vaccine: StudyNo Extra Blood Clot Risk After Second Dose Of AstraZeneca Covid Vaccine: StudyCo-developed by the University of Oxford, the AstraZeneca COVID-19 vaccine is based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees

Highlights
  • AstraZeneca vaccine is known as Covishield in India
  • AstraZeneca vaccine uses a weakened version of a common cold virus
  • AstraZeneca vaccine has been granted emergency use in over 80 countries

London: The AstraZeneca COVID-19 vaccine is associated with a small risk of rare blood clots after the first dose, and no extra risk after the second shot, according to a study led and funded by the British-Swedish drugmaker. The research, published in The Lancet on Tuesday (July 27), shows that the rates of the very rare clotting disorder, thrombosis with thrombocytopenia syndrome (TTS), following a second dose of the vaccine are comparable to those among unvaccinated population.

Also Read:  Understanding The Pace Of India’s Coronavirus Vaccination Drive

TTS is a very rare syndrome which occurs when a person has blood clots (thrombosis) as well as low platelet counts (thrombocytopenia). It is also referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT). Rare cases of TTS have been reported after immunisation with the AstraZeneca vaccine, known as Covishield in India, which led to several countries restricting or stopping the use of the preventive.

The authors demonstrated that the estimated rate of TTS following a second dose of AstraZeneca was 2.3 per million vaccinees, comparable to the rate observed in an unvaccinated population. The rate was 8.1 per million vaccinees after the first dose, they said.

The analysis was conducted using AstraZeneca’s global safety database, which captures all spontaneously reported adverse events from real-world use of its medicines and vaccines worldwide.

Reported cases of TTS globally were included up to the cut-off date of April 30 this year occurring within 14 days of administration of the first or second dose of AstraZeneca vaccine. The results are in line with recent reports in the Medicines and Healthcare products Regulatory Agency (MHRA) Yellow Card Report, the UK system for collecting and monitoring information on safety concerns, which also show low rates of TTS after a second dose, AstraZeneca said.

No specific risk factors or definitive cause for TTS following COVID-19 vaccination have been identified and AstraZeneca continues to perform and support ongoing investigations of potential mechanisms. Furthermore, these very rare events can be avoided when symptoms are identified and treated appropriately, the company said in a statement.

Co-developed by the University of Oxford, the AstraZeneca vaccine is based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees. The preventive contains the genetic material of the SARS-CoV-2 virus spike protein, which the virus uses to enter and infect the human cells. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body. According to its manufacturers, the AstraZeneca vaccine has been granted emergency use in more than 80 countries across six continents.

Also Read: Will Third Wave Be Severe? When Can Children Get COVID-19 Vaccine? AIIMS Chief Dr Randeep Guleria Tells NDTV

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

19,53,13,710Cases

6,27,57,461Active

12,83,78,979Recovered

41,77,270Deaths

Coronavirus has spread to 194 countries. The total confirmed cases worldwide are 19,53,13,710 and 41,77,270 have died; 6,27,57,461 are active cases and 12,83,78,979 have recovered as on July 28, 2021 at 3:50 am.

India

3,14,84,605 43,654Cases

3,99,436 1,336Active

3,06,63,147 41,678Recovered

4,22,022 640Deaths

In India, there are 3,14,84,605 confirmed cases including 4,22,022 deaths. The number of active cases is 3,99,436 and 3,06,63,147 have recovered as on July 28, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

62,76,057 6,258

85,447 6,641

60,58,751 12,645

1,31,859 254

Kerala

33,05,245 22,129

1,45,876 8,558

31,43,043 13,415

16,326 156

Karnataka

28,97,664 1,501

22,510 570

28,38,717 2,039

36,437 32

Tamil Nadu

25,52,049 1,767

22,188 574

24,95,895 2,312

33,966 29

Andhra Pradesh

19,57,932 1,540

20,965 783

19,23,675 2,304

13,292 19

Uttar Pradesh

17,08,226 18

798 59

16,84,674 73

22,754 4

West Bengal

15,24,958 662

11,380 186

14,95,483 838

18,095 10

Delhi

14,36,026 77

570 33

14,10,410 42

25,046 2

Chhattisgarh

10,01,487 128

2,390 128

9,85,578 254

13,519 2

Odisha

9,70,814 1,629

15,830 400

9,49,350 1,969

5,634 60

Rajasthan

9,53,575 15

278 20

9,44,344 34

8,953 1

Gujarat

8,24,774 30

285 27

8,14,413 57

10,076

Madhya Pradesh

7,91,767 11

138 2

7,81,117 13

10,512

Haryana

7,69,796 26

701 10

7,59,471 34

9,624 2

Bihar

7,24,597 67

484 16

7,14,474 51

9,639

Telangana

6,42,436 645

9,237 88

6,29,408 729

3,791 4

Punjab

5,98,882 42

583 54

5,82,018 93

16,281 3

Assam

5,61,455 1,436

15,035 106

5,41,240 1,312

5,180 18

Jharkhand

3,47,022 39

247 1

3,41,650 37

5,125 1

Uttarakhand

3,41,874 96

659 21

3,33,854 73

7,361 2

Jammu And Kashmir

3,20,866 107

1,124 76

3,15,367 183

4,375

Himachal Pradesh

2,05,383 183

923 65

2,00,942 116

3,518 2

Goa

1,70,729 148

1,130 7

1,66,459 151

3,140 4

Puducherry

1,20,530 113

923 14

1,17,816 98

1,791 1

Manipur

94,821 1,165

10,802 278

82,521 876

1,498 11

Tripura

77,412 415

3,754 70

72,910 344

748 1

Meghalaya

62,473 710

5,332 248

56,101 453

1,040 9

Chandigarh

61,938 7

37 1

61,092 6

809

Arunachal Pradesh

46,800 443

4,287 32

42,292 472

221 3

Mizoram

35,297 1,845

10,924 1,420

24,233 422

140 3

Nagaland

27,472 110

1,316 60

25,606 45

550 5

Sikkim

25,616 277

3,075 105

22,208 170

333 2

Ladakh

20,314 5

70 0

20,037 5

207

Dadra And Nagar Haveli

10,639 2

44 1

10,591 3

4

Lakshadweep

10,149 8

82 0

10,018 8

49

Andaman And Nicobar Islands

7,530

12 2

7,389 2

129